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Chaohua Zhang Selected Research

STA 9090

6/2015The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer.
2/2014Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib.
2/2014Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.
1/2014Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
4/2013Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer.
1/2013Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression.
12/2012Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib.
12/2012Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.

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Chaohua Zhang Research Topics

Disease

14Neoplasms (Cancer)
01/2020 - 12/2012
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2015 - 12/2012
3Cicatrix (Scar)
03/2021 - 11/2019
3Wounds and Injuries (Trauma)
06/2020 - 11/2019
3Autolysis
01/2020 - 07/2008
2Inflammation (Inflammations)
03/2021 - 05/2020
2Hyperplasia
05/2020 - 11/2019
2Urinary Bladder Neoplasms (Bladder Cancer)
01/2020 - 07/2014
2Infections
06/2019 - 09/2015
1Lactation Disorders
04/2022
1Genomic Instability
01/2018
1Hypoxia (Hypoxemia)
11/2017
1Hypertension (High Blood Pressure)
07/2017
1Rectal Neoplasms (Rectal Cancer)
01/2017
1Colorectal Neoplasms (Colorectal Cancer)
01/2017
1Breast Neoplasms (Breast Cancer)
02/2014
1Melanoma (Melanoma, Malignant)
02/2014
1Inflammatory Breast Neoplasms
02/2014
1Neoplasm Metastasis (Metastasis)
01/2014
1Triple Negative Breast Neoplasms
01/2014
1Prostatic Neoplasms (Prostate Cancer)
01/2013
1Lung Neoplasms (Lung Cancer)
12/2012

Drug/Important Bio-Agent (IBA)

8STA 9090IBA
06/2015 - 12/2012
7Proteins (Proteins, Gene)FDA Link
05/2020 - 07/2008
5CollagenIBA
03/2021 - 11/2019
5Molecular Chaperones (Chaperone, Molecular)IBA
07/2014 - 12/2012
4Peptides (Polypeptides)IBA
04/2022 - 07/2017
4Amino AcidsFDA Link
01/2020 - 07/2008
3Pharmaceutical PreparationsIBA
11/2015 - 12/2012
2Transcription Factors (Transcription Factor)IBA
06/2019 - 02/2014
2Glucose (Dextrose)FDA LinkGeneric
11/2017 - 07/2014
2NAD (NADH)IBA
11/2017 - 01/2017
2Protein HydrolysatesFDA Link
07/2017 - 07/2008
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
02/2014 - 02/2014
2Heat-Shock Proteins (Heat-Shock Protein)IBA
02/2014 - 01/2013
1Hemostatics (Antihemorrhagics)IBA
06/2020
1Eosine Yellowish-(YS) (Eosin)IBA
06/2020
1Hematoxylin (Haematoxylon)IBA
06/2020
1CytokinesIBA
05/2020
1ElastinIBA
05/2020
1Interleukin-6 (Interleukin 6)IBA
01/2020
1Biological ProductsIBA
01/2020
1desloratadine (Aerius)FDA LinkGeneric
01/2020
1Indicators and Reagents (Reagents)IBA
01/2020
1Collagen Type III (Type III Collagen)IBA
12/2019
1Epidermal Growth Factor (EGF)IBA
12/2019
1Cyclin D1IBA
11/2019
1ChromatinIBA
01/2018
1Lysine (L-Lysine)FDA Link
01/2018
1Histones (Histone)IBA
01/2018
1SirtuinsIBA
11/2017
1Histone Deacetylases (Histone Deacetylase)IBA
11/2017
1Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
07/2017
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
07/2017
1DNA (Deoxyribonucleic Acid)IBA
03/2017
1Fluorouracil (Carac)FDA LinkGeneric
01/2017
1Therapeutic UsesIBA
01/2017
1Topoisomerase I InhibitorsIBA
11/2015
1STA-12-8666IBA
11/2015
1Irinotecan (Camptosar)FDA LinkGeneric
11/2015
1Anti-Bacterial Agents (Antibiotics)IBA
09/2015
1Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric
09/2015
1Levofloxacin (Levaquin)FDA Link
09/2015
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2015
1ErbB Receptors (EGF Receptor)IBA
06/2015
1Gefitinib (Iressa)FDA Link
06/2015
1Erlotinib Hydrochloride (CP 358,774)FDA Link
06/2015
1Oncogene Proteins (Oncogene Protein)IBA
05/2014
1Hormones (Hormone)IBA
02/2014
1TAK 733IBA
02/2014
1tyrosine receptor (receptor, tyrosine)IBA
02/2014
1Proto-Oncogene Proteins B-rafIBA
02/2014
1Lapatinib (GW572016)FDA Link
02/2014
1VemurafenibIBA
02/2014
1Phosphotransferases (Kinase)IBA
04/2013
1Anaplastic Lymphoma KinaseIBA
04/2013
1CrizotinibIBA
04/2013
1AndrogensIBA
01/2013
1Androgen Receptors (Androgen Receptor)IBA
01/2013
1Rifabutin (Ansamycin)FDA Link
12/2012
1Docetaxel (Taxotere)FDA Link
12/2012
1PlatinumIBA
12/2012
1Taxoids (Taxanes)IBA
12/2012
1Paclitaxel (Taxol)FDA LinkGeneric
12/2012
1Flavoring AgentsIBA
07/2008
1Valine (L-Valine)FDA Link
07/2008
1Tyrosine (L-Tyrosine)FDA Link
07/2008
1Tryptophan (L-Tryptophan)FDA Link
07/2008
1Histidine (L-Histidine)FDA Link
07/2008
1Threonine (L-Threonine)FDA Link
07/2008
1Serine (L-Serine)FDA Link
07/2008
1Isoleucine (L-Isoleucine)FDA Link
07/2008
1EnzymesIBA
07/2008

Therapy/Procedure

6Therapeutics
03/2017 - 12/2012
2Drug Therapy (Chemotherapy)
01/2014 - 12/2012
1Oral Administration
12/2019
1Radiotherapy
01/2017
1Intravenous Infusions
09/2015